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IMPACT Study

The Psychiatric Neurogenetics Section at CAMH has received funding from the Ontario Ministry of Research and Innovation to conduct a seven year study to identify genetic variants that influence psychiatric drug response and side effects. The project will focus on individuals receiving antipsychotics and antidepressants.

The overall goal is to improve healthcare to individuals on psychiatric drugs by proactively selecting the appropriate drug and the optimum starting dosage based on the patient’s genetic information. The genes to be tested include liver enzymes for drug metabolism and other genes involved in response and side effects. We expect that patient satisfaction and safety should improve, and healthcare costs will be reduced.


We invite you to share the details of our study with your patients who are eligible. This would be anyone 7 years of age and older who:

  1. is about to start new antipsychotic/antidepressant medication
  2. is switching to a new antipsychotic/antidepressant medication
  3. has been on antipsychotic/antidepressant medication with inadequate response
  4. has experienced significant and repeated side effects

What is Involved?


Participants will be asked to provide a saliva sample for DNA testing and to answer questions regarding their symptoms, medication history and side effects. This will take approximately 45 minutes and he/she will be reimbursed $20.00 for their time.

Test Results


The test results may be helpful to you in trying to find the best possible dose of a medication or choosing a new medication for your patients. However, this form of genetic testing is still being evaluated and test results will not be used alone to make decisions about your medical treatment.




Get in Touch

Centre for Addiction and Mental Health
250 College Street
Toronto, Ontario
M5T 1R8
(416) 535-8501 Ext. 30240
1 (800) 928-3316
(416) 979-4666