The IMPACT research study uses genetic testing to determine specific enzymes and genes related to medication action. Medications are metabolized and activated by a large family of liver enzymes. Metabolic activity of liver enzymes can be indicated by genetically identifying the genes responsible for them.
In the IMPACT study, genetic testing is used to determine the specific forms of liver enzymes individuals carry, and other genes related to medication action. In order to determine the type of liver enzymes, a small sample of saliva is obtained from all participants. DNA is extracted from the collected saliva in order to perform genetic testing. Information about their past and present medications, medical history, family’s medical history, current medical condition, ancestry and treatments are also collected through questionnaires.
Currently, drug medications are administered by ‘trial-and-error’. Patients may not benefit from a specific treatment, and those who do may incur serious side effects. In individualized medicine, the patient’s specific information is used to achieve greater diagnostic precision, to identify and execute more effective therapeutic regimes, and, eventually, to achieve speedier and effective recovery.
Pharmacogenetics is the study of how an individual’s genes affect his or her response to drugs, combining traditional pharmaceutical sciences and biochemistry with knowledge of genes, proteins and polymorphisms.
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